c-Met is a proto-oncogene responsible for encoding the high-affinity receptor for hepatocyte growth factor (HGF). Hepatocyte growth factor is also known as scatter factor which participates in HGF/c-MET signaling pathway. This pathway plays vital role in mitogenesis and morphogenesis during embryonic development and wound healing. The controlled natural activity of c-Met and HGF is important in mammalian development, tissue maintenance, and repair. Binding of HGF to c-MET receptor induces several biological responses collectively known as invasive growth program. These responses are elicited due to activation of several pathways such as RAS pathway, PI3K pathway, STAT pathway, beta-catenin pathway and Notch pathway. However, dysregulation of the HGF/c-MET signaling pathway has been associated with the progression of cancers through activation of oncogenic pathways, angiogenesis and metastasis.
The major cancers such as breast, colon and non-small-cell lung carcinoma (NSCLC) are being examined for efficacy with c-MET / HGF inhibitors. Several small molecule c-Met kinase inhibitors have demonstrated clinical efficacy in cancer treatment and many clinical trials are underway. However, as the small molecule inhibitors lack specificity or selectivity they can cause toxicity. Therefore, researchers are increasing focus to develop antibody therapeutics against c-Met or HGF.
The global C-MET / HGF Inhibitors market is valued at xx million US$ in 2018 is expected to reach xx million US$ by the end of 2025, growing at a CAGR of xx% during 2019-2025.
This report focuses on C-MET / HGF Inhibitors volume and value at global level, regional level and company level. From a global perspective, this report represents overall C-MET / HGF Inhibitors market size by analyzing historical data and future prospect. Regionally, this report focuses on several key regions: North America, Europe, China and Japan.
At company level, this report focuses on the production capacity, ex-factory price, revenue and market share for each manufacturer covered in this report.
The following manufacturers are covered:
Abxign
Abbott Laboratories
Amgen
ArQule
Astex Therapeutics
AVEO Pharmaceuticals
Bristol-Myers Squibb(BMS)
Chroma Therapeutics
Daiichi Sankyo
Deciphera Pharmaceuticals
Eisai
Eli Lilly
Exelixis
Genmab
Galaxy Biotech
GlaxoSmithKline(GSK)
Hutchison MediPharma
Johnson & Johnson
Kringle Pharmaceuticals
Merck
Methylgene
Novartis
Pfizer
ProMetic BioTherapeutics
Takeda Pharmaceutical
Segment by Regions
North America
Europe
China
Japan
Segment by Type
C-Met Biologic Inhibitors
Small Molecule C-Met Inhibitors
HGF Antagonist Antibodies
C-Met Antagonist Antibodies(MetMAb)
HGF Kringle Variant Antagonists
Segment by Application
Hospital Pharmacies
Retail Pharmacies
Drug Stores
Online Sales
Table of Contents
Executive Summary
1 C-MET / HGF Inhibitors Market Overview
1.1 Product Overview and Scope of C-MET / HGF Inhibitors
1.2 C-MET / HGF Inhibitors Segment by Type
1.2.1 Global C-MET / HGF Inhibitors Production Growth Rate Comparison by Type (2014-2025)
1.2.2 C-Met Biologic Inhibitors
1.2.3 Small Molecule C-Met Inhibitors
1.2.4 HGF Antagonist Antibodies
1.2.5 C-Met Antagonist Antibodies(MetMAb)
1.2.6 HGF Kringle Variant Antagonists
1.3 C-MET / HGF Inhibitors Segment by Application
1.3.1 C-MET / HGF Inhibitors Consumption Comparison by Application (2014-2025)
1.3.2 Hospital Pharmacies
1.3.3 Retail Pharmacies
1.3.4 Drug Stores
1.3.5 Online Sales
1.4 Global C-MET / HGF Inhibitors Market by Region
1.4.1 Global C-MET / HGF Inhibitors Market Size Region
1.4.2 North America Status and Prospect (2014-2025)
1.4.3 Europe Status and Prospect (2014-2025)
1.4.4 China Status and Prospect (2014-2025)
1.4.5 Japan Status and Prospect (2014-2025)
1.5 Global C-MET / HGF Inhibitors Market Size
1.5.1 Global C-MET / HGF Inhibitors Revenue (2014-2025)
1.5.2 Global C-MET / HGF Inhibitors Production (2014-2025)
2 Global C-MET / HGF Inhibitors Market Competition by Manufacturers
2.1 Global C-MET / HGF Inhibitors Production Market Share by Manufacturers (2014-2019)
2.2 Global C-MET / HGF Inhibitors Revenue Share by Manufacturers (2014-2019)
2.3 Global C-MET / HGF Inhibitors Average Price by Manufacturers (2014-2019)
2.4 Manufacturers C-MET / HGF Inhibitors Production Sites, Area Served, Product Types
2.5 C-MET / HGF Inhibitors Market Competitive Situation and Trends
Summary: Get latest Market Research Reports on C-MET / HGF Inhibitors. Industry analysis & Market Report on C-MET / HGF Inhibitors is a syndicated market report, published as Global C-MET / HGF Inhibitors Market Research Report 2019. It is complete Research Study and Industry Analysis of C-MET / HGF Inhibitors market, to understand, Market Demand, Growth, trends analysis and Factor Influencing market.