Liquid biopsy is process of obtaining non-solid tissue usually the blood and other body fluids (urine, saliva etc.) obtained non-invasively as a diagnosis and monitoring tool for disease such as cancer through identification of biomarker in form of cell-fee DNA or circulating tumor cells (CTC) to advance personalized medicine, and improve the quality of life. The groundbreaking discovery of cfDNA in 1948 has opened up to new possibilities in the field of oncology, transplantation and non-invasive prenatal screening.
According to IQ4I analysis, the liquid biopsy global market is projected to grow at double digit CAGR to reach $8,730.4 million by 2024.
The liquid biopsy market by Biomarkers is segmented into circulating tumor cells (CTC), cell-free DNA and Exosomes & Others, among which, the Cell-free DNA market commanded the largest share of the market & growing at double digit CAGR from 2017-2024. The utilization of circulating tumor cell as an invaluable research tool is expected to propel this market at a strong CAGR from 2017 to 2024.
The applications market is segmented into oncology testing, prenatal (NIPT) testing and transplantation diagnostics where oncology testing dominates the application with market which is followed by prenatal testing (NIPT) in 2017, however, the rapid adoption of cfDNA based transplantation diagnostics testing is expected to drive this market at strong CAGR during forecasting period.
The oncology testing market is segmented based on type of cancer into breast cancer, colorectal cancer, lung cancer, prostate cancer, melanoma, ovarian cancer and others, where, breast cancer commanded largest share in 2017, lung cancer is projected to grow at highest CAGR from 2017 to 2024. The oncology testing market is segmented based on cancer care into early screening, companion diagnostics, prognosis and recurrence monitoring. The companion diagnostics monitoring market dominates with share in 2017, while early screening is expected to grow at strong CAGR of 22.3% from 2017 to 2024.
The liquid biopsy sample market includes into blood, urine and others where blood dominates the market revenue of $1,881.9 million in 2017 and is expected to maintain the position with strong CAGR growth during forecasting period.
The end-users market is segmented into Hospitals and academic and research institutes. Hospitals attracted the largest revenue in 2017 and are expected to show strong CAGR from 2017 to 2024.
The liquid biopsy geographical market consists of North America, Europe, Asia-Pacific and RoW where North America dominates the market in 2017 followed by Europe. Asia-Pacific market is expected to show highest growth rate during forecasting period.
The report provides an in depth market analysis of the above mentioned segments across the following regions:
• North America
• Europe
• Asia-Pacific
• Rest of the World (RoW)
1 EXECUTIVE SUMMARY 27
2 INTRODUCTION 36
2.1 KEY TAKE AWAYS 36
2.2 REPORT DESCRIPTION 37
2.3 MARKETS COVERED 39
2.4 STAKEHOLDERS 41
2.5 RESEARCH METHODOLOGY 41
2.5.1 MARKET SIZE ESTIMATION 42
2.5.2 MARKET CRACKDOWN AND DATATRIANGULATION 45
2.5.3 SECONDARY SOURCES 46
2.5.4 KEY DATA POINTS FROM SECONDARY SOURCES 47
2.5.5 PRIMARY SOURCES 47
2.5.6 KEY DATA POINTS FROM PRIMARY SOURCES 48
2.5.7 ASSUMPTIONS 48
3 MARKET ANALYSIS 50
3.1 INTRODUCTION 50
3.2 MARKET SEGMENTATION 51
3.3 FACTORS INFLUENCING MARKET 53
3.3.1 DRIVERS AND OPPORTUNITIES 54
3.3.1.1 Rising incidence of cancer 54
3.3.1.2 increasing preference for blood/urine based liquid biopsy over invasive tissue
biopsy procedures 55
3.3.1.3 rising number of late pregnancies leading to high incidence rate of babies with chromosomal disorders 56
3.3.1.4 Increasing funding for liquid based test development 57
3.3.1.5 Technological advancements in liquid biopsy 57
3.3.1.6 Agreements and collaborations 58
3.3.1.7 Increasing number of liquid biopsy test launches 59
3.3.2 RESTRAINTS AND THREATS 60
3.3.2.1 High cost with less reimbursement facilities 60
3.3.2.2 Ethical issues related to genetic testing 60
3.3.2.3 Lack of skilled healthcare professionals 61
3.3.2.4 Lack of standardization of liquid biopsy tests 61
3.3.2.5 Regulatory issues 62
3.4 REGULATORY AFFAIRS 63
3.4.1 U.S. 63
3.4.2 EUROPE 63
3.4.3 CHINA 64
3.4.4 INDIA 65
3.4.5 JAPAN 65
3.5 PORTER’S FIVE FORCE ANALYSIS 66
3.5.1 THREAT OF NEW ENTRANTS 67
3.5.2 THREAT OF SUBSTITUTES 67
3.5.3 COMPETITIVE RIVALRY 67
3.5.4 BARGAINING POWER OF SUPPLIERS 68
3.5.5 BARGAINING POWER OF BUYERS 69
3.6 PATENT TRENDS 69
3.7 MARKET SHARE ANALYSIS 71
3.8 REIMBURSEMENT SCENARIO 77
3.9 CLINICAL TRIALS 80
3.10 TECHNOLOGICAL ADVANCEMENTS 97
3.10.1 MICRORNA (MIRNA) 97
3.10.2 PROTEIN BIOMARKERS 98
3.10.3 CIRCULATING MRNA 98
3.10.4 CRISPR PAPER TEST (SHERLOCK) 98
3.11 UPCOMING TESTS 99
3.12 RESEARCH USE ONLY CELL-FREE DNA TESTS 102
3.13 FUNDING SCENARIO 104
3.14 LIQUID BIOPSY COMPANY COMPARISON BY APPLICATIONS 114
4 MARKET SIZING 126
4.1 U.S.LIQUID BIOPSY MARKET SIZING INFORMATION 126
4.1.1 ONCOLOGY TESTING 127
4.1.1.1 Early screening 127
4.1.1.2 Companion diagnostics 127
4.1.1.3 Prognosis monitoring 129
4.1.1.4 Recurrence monitoring 130
4.1.2 NON-INVASIVE PRENATAL SCREENING (NIPT) 131
4.1.3 TRANSPLANTATION DIAGNOSTICS 132
5 LIQUID BIOPSY GLOBAL MARKET, BY BIOMARKER 134
5.1 INTRODUCTION 134
5.2 CIRCULATING TUMOUR CELLS (CTC) 137
5.3 CELL-FREE DNA (CFDNA) 141
5.4 EXOSOMES & OTHERS 144
6 LIQUID BIOPSY GLOBAL MARKET, BY APPLICATION 149
6.1 INTRODUCTION 149
6.2 ONCOLOGY TESTING 152
6.2.1 CANCER TYPES 154
6.2.1.1 Introduction 154
6.2.1.2 Lung cancer 159
6.2.1.3 Breast cancer 165
6.2.1.4 Colorectal cancer 169
6.2.1.5 Melanoma 175
6.2.1.6 Prostate cancer 177
6.2.1.7 Ovarian cancer 182
6.2.1.8 Others 184
6.2.2 CANCER CARE 190
6.2.2.1 Introduction 190
6.2.2.2 Early screening 192
6.2.2.3 Companion diagnosis 195
6.2.2.4 Prognosis monitoring 197
6.2.2.5 Recurrence monitoring 200
6.3 PRENATAL TESTING 203
6.4 TRANSPLANTATION 206
7 LIQUID BIOPSY GLOBAL MARKET, BY SAMPLE 209
7.1 INTRODUCTION 209
7.2 BLOOD 211
7.3 URINE AND OTHERS 215
8 LIQUID BIOPSY GLOBAL MARKET, BY END-USERS 219
8.1 INTRODUCTION 219
8.2 HOSPITALS 222
8.3 ACADEMIC & RESEARCH INSTITUTES 225
9 REGIONAL ANALYSIS 229
9.1 INTRODUCTION 229
9.2 NORTH AMERICA 232
9.2.1 UNITED STATES 246
9.2.2 OTHERS 250
9.3 EUROPE 254
9.3.1 GERMANY 268
9.3.2 FRANCE 272
9.3.3 U.K. 276
9.3.4 OTHERS 280
9.4 ASIA-PACIFIC 284
9.4.1 JAPAN 298
9.4.2 CHINA 302
9.4.3 INDIA 306
9.4.4 OTHERS 310
9.5 REST OF THE WORLD (ROW) 314
9.5.1 BRAZIL 328
9.5.2 REST OF LATIN AMERICA 332
9.5.3 MIDDLE EAST & OTHERS 336
10 COMPETITIVE LANDSCAPE 340
10.1 INTRODUCTION 340
10.2 AGREEMENTS 341
10.3 COLLABORATIONS/PARTNERSHIPS 354
10.4 NEW PRODUCT LAUNCHES 362
10.5 APPROVALS 370
10.6 ACQUSTIONS 372
10.7 OTHERS 374
11 MAJOR COMPANIES 382
11.1 BGI (BGI DIAGNOSTICS) 382
11.1.1 OVERVIEW 382
11.1.2 FINANCIALS 382
11.1.3 PRODUCTS NIFTY TEST 382
11.1.4 KEY DEVELOPMENTS 383
11.1.5 BUSINESS STRATEGY 385
11.1.6 SWOT ANALYSIS 386
11.2 BIOCEPT, INC. 387
11.2.1 OVERVIEW 387
11.2.2 FINANCIALS 388
11.2.3 PRODUCT PORTFOLIO 388
11.2.4 KEY DEVELOPMENTS 389
11.2.5 BUSINESS STRATEGY 398
11.2.6 SWOT ANALYSIS 399
11.3 CAREDX, INC. 400
11.3.1 OVERVIEW 400
11.3.2 FINANCIALS 401
11.3.3 PRODUCT DESCRIPTION 403
11.3.4 KEY DEVELOPMENTS 404
11.3.5 BUSINESS STRATEGY 406
11.3.6 SWOT ANALYSIS 407
11.4 CYNVENIO BIOSYSTEMS, INC 408
11.4.1 OVERVIEW 408
11.4.2 FINANCIALS 408
11.4.3 PRODUCT PORTFOLIO 409
11.4.4 KEY DEVELOPMENTS 409
11.4.5 BUSINESS STRATEGY 413
11.4.6 SWOT ANALYSIS 414
11.5 EUROFINS SCIENTIFIC SE (LIFECODEXX) 415
11.5.1 OVERVIEW 415
11.5.2 FINANCIALS 416
11.5.3 PRODUCT PORTFOLIO 417
11.5.4 KEY DEVELOPMENTS 418
11.5.5 BUSINESS STRATEGY 420
11.5.6 SWOT ANALYSIS 421
11.6 EXACT SCIENCES CORPORATION 422
11.6.1 OVERVIEW 422
11.6.2 FINANCIALS 423
11.6.3 PRODUCT PORTFOLIO 423
11.6.4 KEY DEVELOPMENTS 424
11.6.5 BUSINESS STRATEGY 425
11.6.6 SWOT ANALYSIS 426
11.7 EXOSOME DIAGNOSTICS, INC 427
11.7.1 OVERVIEW 427
11.7.2 FINANCIALS 427
11.7.3 PRODUCT PORTFOLIO 428
11.7.4 KEY DEVELOPMENTS 428
11.7.5 BUSINESS STRATEGY 432
11.7.6 SWOT ANALYSIS 433
11.8 GUARDANT HEALTH, INC. 434
11.8.1 OVERVIEW 434
11.8.2 FINANCIALS 434
11.8.3 PRODUCT DESCRIPTION 434
11.8.4 KEY DEVELOPMENTS 435
11.8.5 BUSINESS STRATEGY 441
11.8.6 SWOT ANALYSIS 442
11.9 ILLUMINA, INC. 443
11.9.1 OVERVIEW 443
11.9.2 FINANCIALS 444
11.9.3 PRODUCT PORTFOLIO 446
11.9.4 KEY DEVELOPMENTS 447
11.9.5 BUSINESS STRATEGY 448
11.9.6 SWOT ANALYSIS 449
11.10 IMMUCOR 450
11.10.1 OVERVIEW 450
11.10.2 FINANCIALS 451
11.10.3 PRODUCT PORTFOLIO 453
11.10.4 KEY DEVELOPMENTS 454
11.10.5 BUSINESS STRATEGY 454
11.10.6 SWOT ANALYSIS 455
11.11 LABORATORY CORPORATION OF AMERICA HOLDINGS 456
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