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Prostaglandin D2 Receptor 2 - Pipeline Review, H2 2019

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Table of Contents

    List of Tables

      List of Figures

        Introduction

          Global Markets Direct Report Coverage

            Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) - Overview

              Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) - Therapeutics Development

                Products under Development by Stage of Development

                  Products under Development by Therapy Area

                    Products under Development by Indication

                      Products under Development by Companies

                        Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) - Therapeutics Assessment

                          Assessment by Mechanism of Action

                            Assessment by Route of Administration

                              Assessment by Molecule Type

                                Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) - Companies Involved in Therapeutics Development

                                  Allergan Plc

                                    Brickell Biotech Inc

                                      Gossamer Bio Inc

                                        HEC Pharm Co Ltd

                                          Idorsia Pharmaceutical Ltd

                                            KBP BioSciences Co Ltd

                                              Merck & Co Inc

                                                Novartis AG

                                                  Oxagen Ltd

                                                    Seelos Therapeutics, Inc.

                                                      Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) - Drug Profiles

                                                        ACT-774312 - Drug Profile

                                                          Product Description

                                                            Mechanism Of Action

                                                              R&D Progress

                                                                ADC-3680 - Drug Profile

                                                                  Product Description

                                                                    Mechanism Of Action

                                                                      R&D Progress

                                                                        BBI-5000 - Drug Profile

                                                                          Product Description

                                                                            Mechanism Of Action

                                                                              R&D Progress

                                                                                fevipiprant - Drug Profile

                                                                                  Product Description

                                                                                    Mechanism Of Action

                                                                                      R&D Progress

                                                                                        KBP-7026 - Drug Profile

                                                                                          Product Description

                                                                                            Mechanism Of Action

                                                                                              R&D Progress

                                                                                                litapiprant - Drug Profile

                                                                                                  Product Description

                                                                                                    Mechanism Of Action

                                                                                                      R&D Progress

                                                                                                        MK-1092 - Drug Profile

                                                                                                          Product Description

                                                                                                            Mechanism Of Action

                                                                                                              R&D Progress

                                                                                                                MK-8318 - Drug Profile

                                                                                                                  Product Description

                                                                                                                    Mechanism Of Action

                                                                                                                      R&D Progress

                                                                                                                        setipiprant - Drug Profile

                                                                                                                          Product Description

                                                                                                                            Mechanism Of Action

                                                                                                                              R&D Progress

                                                                                                                                SLS-008 - Drug Profile

                                                                                                                                  Product Description

                                                                                                                                    Mechanism Of Action

                                                                                                                                      R&D Progress

                                                                                                                                        Small Molecules to Antagonize PTGDR2 for Asthma - Drug Profile

                                                                                                                                          Product Description

                                                                                                                                            Mechanism Of Action

                                                                                                                                              R&D Progress

                                                                                                                                                Timapiprant - Drug Profile

                                                                                                                                                  Product Description

                                                                                                                                                    Mechanism Of Action

                                                                                                                                                      R&D Progress

                                                                                                                                                        Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) - Dormant Products

                                                                                                                                                          Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) - Discontinued Products

                                                                                                                                                            Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) - Product Development Milestones

                                                                                                                                                              Featured News & Press Releases

                                                                                                                                                                Nov 08, 2019: Gossamer announces data presentations at the American College of Allergy, Asthma and Immunology Annual Scientific Meeting 2019

                                                                                                                                                                  Feb 13, 2019: Asthma pill targets airway muscles to decrease attacks

                                                                                                                                                                    Nov 05, 2018: Novartis provides update on QAW039

                                                                                                                                                                      Jan 30, 2018: Novartis India granted permission for conduct Of Clinical Trial in India for its Asthma Drug

                                                                                                                                                                        Dec 14, 2016: Pulmagen Therapeutics announces positive data for ADC3680, a once daily, orally administered CRTh2 antagonist in eosinophilic asthma patients in a 16-week Phase II study conducted in Japan by partner Teijin Pharma

                                                                                                                                                                          Sep 28, 2016: Eleventa Announce Completion of Patient Enrollment in Phase 3 Clinical Trial of CRTH2 Antagonist Timapiprant for the Treatment of Allergic Asthma

                                                                                                                                                                            Aug 05, 2016: Asthma pill could reduce symptoms in severe sufferers

                                                                                                                                                                              Feb 17, 2016: Update on Phase 2 clinical trial with OC459 in patients with moderate to severe atopic dermatitis

                                                                                                                                                                                Sep 22, 2015: KYTHERA Biopharmaceuticals Submits Investigational New Drug Application for KYTH-105 to Treat Androgenetic Alopecia, or Male Pattern Hair Loss

                                                                                                                                                                                  Jun 16, 2015: Atopix Therapeutics Secures Funding to Broaden Development of CRTH2 Antagonists for TH2-Mediated Disease

                                                                                                                                                                                    Feb 18, 2015: The US FDA approved KBP-7026 to enter Phase I clinical trial

                                                                                                                                                                                      Aug 01, 2014: Pulmagen’s lead CRTh2 antagonist, ADC3680, completes patient recruitment in Phase II study

                                                                                                                                                                                        Aug 01, 2014: Eleventa has enrolled first patients in Phase III multicenter clinical trial

                                                                                                                                                                                          Jul 28, 2014: Eleventa enrolled the first patients into the multi-center center clinical study of the 3rd phase of antiasthmatic drug

                                                                                                                                                                                            Mar 03, 2014: Atopix Therapeutics Announces Positive Phase IIb Results for Once Daily OC459 in Asthma

                                                                                                                                                                                              Appendix

                                                                                                                                                                                                Methodology

                                                                                                                                                                                                  Coverage

                                                                                                                                                                                                    Secondary Research

                                                                                                                                                                                                      Primary Research

                                                                                                                                                                                                        Expert Panel Validation

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                                                                                                                                                                                                            Disclaimer

                                                                                                                                                                                                            Prostaglandin D2 Receptor 2 - Pipeline Review, H2 2019

                                                                                                                                                                                                            Summary

                                                                                                                                                                                                            According to the recently published report 'Prostaglandin D2 Receptor 2 - Pipeline Review, H2 2019'; Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) pipeline Target constitutes close to 12 molecules. Out of which approximately 12 molecules are developed by Companies.

                                                                                                                                                                                                            Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) - Prostaglandin D2 (PGD2) receptors are G protein-coupled receptors that binds and is activated by prostaglandin D2. It mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation.

                                                                                                                                                                                                            The report 'Prostaglandin D2 Receptor 2 - Pipeline Review, H2 2019' outlays comprehensive information on the Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.

                                                                                                                                                                                                            It also reviews key players involved in Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 2, 3, 3, 1, 2 and 1 respectively. Report covers products from therapy areas Respiratory, Dermatology, Ear Nose Throat Disorders, Gastrointestinal, Hematological Disorders, Immunology and Metabolic Disorders which include indications Asthma, Androgenic Alopecia, Nasal Polyps (Nasal Polyposis), Atopic Dermatitis (Atopic Eczema), Chronic Obstructive Pulmonary Disease (COPD), Chronic Urticaria Or Hives, Eosinophilia, Esophagitis, Inflammation, Rhinosinusitis, Type 1 Diabetes (Juvenile Diabetes) and Type 2 Diabetes.

                                                                                                                                                                                                            Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

                                                                                                                                                                                                            Scope

                                                                                                                                                                                                            - The report provides a snapshot of the global therapeutic landscape for Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2)
                                                                                                                                                                                                            - The report reviews Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
                                                                                                                                                                                                            - The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
                                                                                                                                                                                                            - The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
                                                                                                                                                                                                            - The report reviews key players involved in Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) targeted therapeutics and enlists all their major and minor projects
                                                                                                                                                                                                            - The report assesses Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
                                                                                                                                                                                                            - The report summarizes all the dormant and discontinued pipeline projects
                                                                                                                                                                                                            - The report reviews latest news and deals related to Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) targeted therapeutics

                                                                                                                                                                                                            Reasons to buy

                                                                                                                                                                                                            - Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
                                                                                                                                                                                                            - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
                                                                                                                                                                                                            - Identify and understand the targeted therapy areas and indications for Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2)
                                                                                                                                                                                                            - Identify the use of drugs for target identification and drug repurposing
                                                                                                                                                                                                            - Identify potential new clients or partners in the target demographic
                                                                                                                                                                                                            - Develop strategic initiatives by understanding the focus areas of leading companies
                                                                                                                                                                                                            - Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
                                                                                                                                                                                                            - Devise corrective measures for pipeline projects by understanding Prostaglandin D2 Receptor 2 (Chemoattractant Receptor Homologous Molecule Expressed On Th2 Cells or G Protein Coupled Receptor 44 or GPR44 or CD294 or PTGDR2) development landscape
                                                                                                                                                                                                            - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

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